Phytochemical and pharmacological studies of Lycium schweinfurthii methanolic leaves extract (Solanaceae) in mice

Lycium schweinfurthii is found in stony and sandy places belonging to the Solanaceae family which widely distributed North Africa Mediterranean area. The leaves fruits of this plant have traditionally been used for gastrointestinal diseases. This study was aimed evaluate neuropharmacological activity methanolic extract experimental animals. prepared by fractionation technique. Male Albino mice 22.2 ± 2.1 gm were Irwin primary screening test, diazepam thiopental -induced sleep open field apparatus general locomotor as well analgesic evaluated acetic acid-induced writhing hot-plate. phytochemical performed qualitative quantitative analysis. Diazepam at 2 20 mg/kg, flumazenil 40 diclofenac 25 50 mg/kg indomethacin all references. selected dose 400 after test. significantly prolonged duration diazepam-induced without significant difference onset sleep. Pretreatment with completely blocked hypnotic effects diazepam. did not produce any change time In an open-field a combination produced reduction both exploratory observed four min 30 min, respectively. induced profound central peripheral action. While, showed presences flavonoids, tannins, saponins, phenols, cardiac glycoside, alkaloids carbohydrates extract. total flavonoids most content compounds Thus, these findings indicate that has depression, sedative like activities.